TST, Vol. 16, No. 4, PP. 68-76
(Invited paper) Detection of aqueous ¦Á-lactose based on THz spectroscopy with parallel plate waveguide
Haiqing Wang 1, 2£¬Wei Shi 2*£¬Huanlin Li 2£¬Maojiang Song 2£¬and Juncheng Cao 3
1 School of Physics and Opto-Electronic Technology, Baoji Key Laboratory of Micro-Nano Optoelectronics and Terahertz Technology, Baoji University of Arts and Sciences, Baoji, Shaanxi, China
2 Key Laboratory of Ultrafast Photoelectric Technology and Terahertz Science in Shaanxi, Xi¡¯an University of Technology, Xi¡¯an 710048, China
3 The Key Laboratory of Terahertz Solid-State Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China
*2 Email: swshi@mail.xaut.edu.cn
(Received December 2023)
Abstract: Rapid and accurate identification of the types and level of early pathological markers by THz technology is of great importance for clinical prevention and treatment of major diseases. However, these markers are usually severely attenuated by the strong absorption signal of water, resulting in a low signal-to-noise ratio (SNR), making identification and quantitative analysis difficult. In this paper, a THz - TDS system based on a high-power terahertz (THz) source radiated by LiNbO3, coupled with parallel plate waveguide detection platform, is used to achieve quantitative THz detection of ¦Á-lactose monohydrate solutions with an accuracy of 1.0 mg/¦ÌL. Both its solid and solution have fixed absorption peak at 0.53 THz, while the corresponding absorption baseline increases with decreasing concentration. The high-power radiation source combined with the parallel plate waveguide directly detects water-containing samples, which fundamentally solves the difficulty of capturing the effective signal of aqueous biological samples due to the attenuation of the sample THz signal by water. This method not only avoids the destruction of the biological sample activity, but also has the characteristics of high-cost performance, high detection accuracy and wide application.
Keywords: Terahertz spectroscopy, ¦Á-lactose, Parallel plate waveguide
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