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Dongshan Wei 1, Zhongbo Yang 1, Mingkun Zhang 1, Mingjie Tang 1, Shihan Yan 1, Changcheng Shi 1, Liangping Xia 1, Huabin Wang 1, Tianying Chang 1, 2, Chunlei Du 1, and Hong-Liang Cui 1*, 2
1 Chongqing Key Laboratory of Multi-scale Manufacturing Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, 400714, China
2 College of Instrumentation Science and Electrical Engineering, Jilin University, Changchun, Jilin, 130061, China
*1 Email: hcui@cigit.ac.cn
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Abstract: Terahertz (THz) electromagnetic wave belonging to the frequency band from 0.1 to 10 THz (pundits narrow this range to 0.3-3 THz) has emerged as a powerful tool for investigating biomolecular systems. Since the energy level of THz wave largely coincides with that of the biomolecular low-frequency motions including vibration, rotation and translation of the molecular skeleton and that of the weak intermolecular interactions including hydrogen-bond and van der Waals etc., THz spectroscopy as a molecular detection technology has its unique advantages over some other existing ones. In the last several years, our group has focused on THz spectroscopy detection and spectral imaging of biomolecules, especially on the development of a THz near-field microscopy equipment for imaging of cells and even biomacromolecules. On the theoretical front, we have calculated and analyzed the characteristic spectra of polypeptides and investigated the effects of conformation and size of biomolecules on their THz spectra. Experimentally, microfluidic channels for THz spectroscopy tests were fabricated and the THz spectra of l-DNA were investigated. A scattering-type scanning near-field terahertz microscopy based on the atomic force microscopy and the THz spectrometer was built and initial results about the modulation of the THz near-filed signals were presented.
Keywords: Terahertz spectroscopy, Biomolecule, Absorption coefficient, Near-field microscopy, Molecular dynamics, Microfluidic channel.
Received: 2015-8-18
Published: 2015-9-29
Acknowledgments: This work is part supported by National 973 Program of China (No. 2015CB755401), fundamental & advanced research project of Chongqing, China (cstc2013jcyjC00001), national natural science foundation of China (Nos. 21407145 and 31400625), application development project of Chongqing, China (cstc2013yykfC00007), and scientific equipment research project of Chinese Academy of Sciences (Development of THz imaging spectrometer for biomacromolecules)
Cite this article:
Dongshan Wei, Zhongbo Yang, Mingkun Zhang, Mingjie Tang, Shihan Yan, Changcheng Shi, Liangping Xia, Huabin Wang, Tianying Chang, Chunlei Du, and Hong-Liang Cui. Terahertz spectroscopy of biomolecules[J]. International Journal of Terahertz Science and Technology, 2015, Vol.8, No.3: 101-112. DOI:10.11906/TST.101-112.2015.09.10
URL: http://www.tstnetwork.org/10.11906/TST.101-112.2015.09.10
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